The CONFIDENCE to Live Each Moment
At Alladapt, we believe every person with food allergy deserves to experience more of life’s magical moments with less fear and greater confidence.
To enable this vision, our team of industry-leading scientists and biotechnology professionals is intensely focused on the development of prescription therapeutics for the treatment of food allergy.
Leveraging the growing body of knowledge on the underlying biology of food allergy, we are advancing our mission of developing a single therapeutic to support the management of a broad range of common food allergies.

About Us

We are dedicated to developing and commercializing effective and broadly applicable interventions for food allergy.

Food allergy is a disease of the immune system that is triggered by an exceptionally broad range of commonly allergenic foods such as cow’s milk, eggs, tree nuts, peanuts, shellfish and even sesame. In a perfect world, the human immune system would adapt to all foods. However, in tens of millions of people, the immune system wrongly recognizes some food proteins as harmful and does not adapt. We envision a world where, with help from oral immunotherapy, the immune system can adapt to nearly all food allergens. And we built our inspiration into our name—Alladapt.

Alladapt was co-founded in 2018 in Palo Alto, California, by allergist and protein biochemist Kari Nadeau, MD, PhD, and biotechnology entrepreneur, Ashley Dombkowski, PhD. Academic clinical research conducted by Dr. Nadeau has demonstrated that a food allergic immune system in an individual person can be receptive to remodeling by gradually increasing exposure, under tightly controlled clinical supervision, to the proteins that activate the inappropriate cascade of reactions. This work, combined with research illuminating disease mechanisms and pathways, led the founders to envision a biopharmaceutical intervention capable of addressing food allergy provoked by a wide-ranging set of antigens.

Food allergy is a serious disease, with potentially life-threatening consequences. The disease has grown dramatically in recent years and now affects more than 6 million children¹ and 26 million adults² in the United States alone. Importantly, about half of people with food allergy are reactive to multiple foods, which further increases the risk of anaphylaxis due to accidental ingestion.

The chronic, unpredictable components of this disease can elevate anxiety in patients and their families, and place extreme limitations on their lives. It is our goal to help patients experience more of life’s magical moments with less fear and greater confidence.

¹ Gupta, R. S., Warren, C. M., Smith, B. M., Blumenstock, J. A., Jiang, J., Davis, M. M., et al. (2018). "The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States." Pediatrics 142(6).

² Gupta, R. S., Warren, C. M., Smith, B. M., Jiang, J., Blumenstock, J. A., Davis, M. M., et al. (2019). "Prevalence and Severity of Food Allergies Among US Adults." JAMA Netw Open 2(1): e185630.

Science

Food allergy is a disease that can be triggered by an expansive set of antigens. We are developing an oral prescription therapy with this in mind.

ADP101, our lead drug candidate, is being developed for the mitigation of food allergy provoked by either single or multiple proteins from a wide-ranging set of foods. We are working to formulate this proprietary oral immunotherapy drug candidate as a single agent capable of delivering highly-consistent, well-characterized, precisely-dosed protein from the vast majority of commonly allergenic protein families. ADP101 is based on an intellectual property estate that includes patents and accompanying clinical data licensed from Stanford University.

Presentations and Publications

--Ashley to consider adding list of presentations and publications--

Since 20XX, many publications have focused on food allergy as a single disease...

-- List of presentations and publications --

Patients

We strive to understand the needs of the patient community.

We bring an unwavering commitment to collaborating with patients, family members and physicians so that the values and needs of stakeholders in the food allergy community can be incorporated into our program. Our foundational research was originally inspired by insights shared with us by patients and families who were frustrated by the absence of adequate treatment options for such a serious disease. Our outreach revealed:

  • Food allergic patients must avoid a larger set of trigger foods than typically recognized by society, thereby increasing the challenges of keeping patients protected
  • Food allergic patients are increasingly reactive to multiple trigger foods, appearing in many different combinations
  • In addition to the immune components of food allergy, the psychological and social dimensions of the disease must be taken into consideration in order to truly align with patient needs

These insights, and the voices of patients, are at the heart of everything we do at Alladapt.

In an effort to support food allergy advocacy and advance a broader understanding of this serious and complex disease, we have compiled the following links. Whether you are a patient, a family member, or someone seeking a better understanding of this disease, these resources may be useful. Please note these links will take you away from the Alladapt website to sites that are maintained by independent groups.

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News

Team

Leadership Team

Our leadership team is dedicated to developing prescription therapeutics that help patients with food allergy.

Ashley Dombkowski, PhD
Chief Executive Officer and Co-Founder
Dana McClintock, MD
Chief Medical Officer
Jim Kirchner, PhD
Vice President of Manufacturing and CMC
Preeti Lal, PhD
Vice President of Development Sciences and Translational Medicine
Amelia Milani, MBA
Vice President of Supply Chain and Operations
Amy Sullivan
Vice President of Development Operations
Sid Reddy, CPA
Director of Finance

Alladapt’s Board of Directors and Advisors bring diverse capabilities and broad expertise that they contribute to our mission.

Board of Directors

Ashley Dombkowski, PhD
CEO, Alladapt
Greg Horn
Managing Director, William Hood and Company
CEO of Specialty Nutrition Consulting
Sophie Kornowski, PharmD
Senior Partner at Gurnet Point Capital
Former Executive Vice-President of Roche Partnering
Christopher Viehbacher
Managing Partner at Gurnet Point Capital
Former Chief Executive Officer of Sanofi

Clinical and Scientific Advisors

Eugene Bauer, MD
Co-founder and CMO of Dermira
Former Dean of the School of Medicine and Vice President for Medical Affairs, Stanford University
Sharon Chinthrajah, MD
Clinical Associate Professor of Medicine, Pediatrics Immunology and Allergy at Stanford
Thomas Fleming, PhD
Professor of Biostatistics at University of Washington
Susannah Fox
Health and Technology Researcher
Former Chief Technology Officer, U.S. Department of Health and Human Services
Ruchi Gupta, MD
Professor of Pediatrics and Medicine at Northwestern Medicine
Director of the Center for Food Allergy & Asthma Research, Northwestern Institute for Public Health and Medicine
Attending physician at Ann & Robert H. Lurie Children's Hospital Chicago
Kari Nadeau, MD, PhD
Director of the Sean N. Parker Center for Allergy and Asthma Research at Stanford University
Section Chief of Allergy and Asthma at the Stanford School of Medicine
Professor under the Naddisy Family Foundation
Dale Umetsu, MD, PhD
Adjunct Clinical Professor of Medicine, Pulmonary & Critical Care Medicine at Stanford
Christopher T. Walsh, PhD
Emeritus Faculty, Harvard Medical School, Advisor to Stanford’s ChEM-H Institute
Scientific Advisory Board Member to the Broad Institute of Harvard and MIT
Senior Associate Member to the Broad Institute of Harvard and MIT
Former President of the Dana-Farber Cancer Institute

Contact

How can we advance the Alladapt mission together?

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